Matrine suppresses breast cancer metastasis by targeting ITGB1 and inhibiting epithelial-to-mesenchymal transition
Identifieur interne : 000650 ( Main/Exploration ); précédent : 000649; suivant : 000651Matrine suppresses breast cancer metastasis by targeting ITGB1 and inhibiting epithelial-to-mesenchymal transition
Auteurs : Lili Ren [République populaire de Chine] ; Wenju Mo [République populaire de Chine] ; Linling Wang [République populaire de Chine] ; Xiaojia Wang [République populaire de Chine]Source :
- Experimental and Therapeutic Medicine [ 1792-0981 ] ; 2019.
Abstract
Metastasis can be a fatal step in breast cancer progression. Effective therapies are urgently required due to the limited therapeutic options clinically available. The aim of the present study was to investigate the effect of matrine (MAT), a traditional Chinese medicine, on the proliferation and migration of human breast cancer cells and its underlying mechanisms of action. The proliferation of MDA-MB-231 cells was inhibited and apoptosis was induced following treatment with MAT, as determined by MTT and Annexin-V-FITC/PI assays. Western blot analysis was used to detect the LC-3II/I levels and the results suggested that tumor autophagy is involved in the anti-tumor activity of MAT. To the best of our knowledge, this is the first study to report that MAT inhibits MDA-MB-231 and MCF-7 cell motility, potentially by targeting integrin β1 (ITGB1) and epithelial-to-mesenchymal transition (EMT), as indicated by Transwell® and siRNA interference assays. In conclusion, ITGB1 and EMT are involved in MAT-induced breast carcinoma cell death and the inhibition of metastasis. This may lead to the development of novel compounds for the treatment of breast cancer metastasis.
Url:
DOI: 10.3892/etm.2019.8207
PubMed: 31853313
PubMed Central: 6909565
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000521
- to stream Pmc, to step Curation: 000521
- to stream Pmc, to step Checkpoint: 000600
- to stream Ncbi, to step Merge: 000D47
- to stream Ncbi, to step Curation: 000D47
- to stream Ncbi, to step Checkpoint: 000D47
- to stream Main, to step Merge: 000650
- to stream Main, to step Curation: 000650
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Matrine suppresses breast cancer metastasis by targeting ITGB1 and inhibiting epithelial-to-mesenchymal transition</title>
<author><name sortKey="Ren, Lili" sort="Ren, Lili" uniqKey="Ren L" first="Lili" last="Ren">Lili Ren</name>
<affiliation wicri:level="1"><nlm:aff id="af1-etm-0-0-8207">Department of Integration of Traditional Chinese and Western Medicine, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Department of Integration of Traditional Chinese and Western Medicine, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022</wicri:regionArea>
<wicri:noRegion>Zhejiang 310022</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mo, Wenju" sort="Mo, Wenju" uniqKey="Mo W" first="Wenju" last="Mo">Wenju Mo</name>
<affiliation wicri:level="1"><nlm:aff id="af2-etm-0-0-8207">Department of Breast Tumor Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Department of Breast Tumor Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022</wicri:regionArea>
<wicri:noRegion>Zhejiang 310022</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Linling" sort="Wang, Linling" uniqKey="Wang L" first="Linling" last="Wang">Linling Wang</name>
<affiliation wicri:level="1"><nlm:aff id="af3-etm-0-0-8207">College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053</wicri:regionArea>
<wicri:noRegion>Zhejiang 310053</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Xiaojia" sort="Wang, Xiaojia" uniqKey="Wang X" first="Xiaojia" last="Wang">Xiaojia Wang</name>
<affiliation wicri:level="1"><nlm:aff id="af4-etm-0-0-8207">Department of Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Department of Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022</wicri:regionArea>
<wicri:noRegion>Zhejiang 310022</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">31853313</idno>
<idno type="pmc">6909565</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909565</idno>
<idno type="RBID">PMC:6909565</idno>
<idno type="doi">10.3892/etm.2019.8207</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000521</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000521</idno>
<idno type="wicri:Area/Pmc/Curation">000521</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000521</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000600</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000600</idno>
<idno type="wicri:Area/Ncbi/Merge">000D47</idno>
<idno type="wicri:Area/Ncbi/Curation">000D47</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000D47</idno>
<idno type="wicri:doubleKey">1792-0981:2019:Ren L:matrine:suppresses:breast</idno>
<idno type="wicri:Area/Main/Merge">000650</idno>
<idno type="wicri:Area/Main/Curation">000650</idno>
<idno type="wicri:Area/Main/Exploration">000650</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Matrine suppresses breast cancer metastasis by targeting ITGB1 and inhibiting epithelial-to-mesenchymal transition</title>
<author><name sortKey="Ren, Lili" sort="Ren, Lili" uniqKey="Ren L" first="Lili" last="Ren">Lili Ren</name>
<affiliation wicri:level="1"><nlm:aff id="af1-etm-0-0-8207">Department of Integration of Traditional Chinese and Western Medicine, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Department of Integration of Traditional Chinese and Western Medicine, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022</wicri:regionArea>
<wicri:noRegion>Zhejiang 310022</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mo, Wenju" sort="Mo, Wenju" uniqKey="Mo W" first="Wenju" last="Mo">Wenju Mo</name>
<affiliation wicri:level="1"><nlm:aff id="af2-etm-0-0-8207">Department of Breast Tumor Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Department of Breast Tumor Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022</wicri:regionArea>
<wicri:noRegion>Zhejiang 310022</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Linling" sort="Wang, Linling" uniqKey="Wang L" first="Linling" last="Wang">Linling Wang</name>
<affiliation wicri:level="1"><nlm:aff id="af3-etm-0-0-8207">College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053</wicri:regionArea>
<wicri:noRegion>Zhejiang 310053</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Xiaojia" sort="Wang, Xiaojia" uniqKey="Wang X" first="Xiaojia" last="Wang">Xiaojia Wang</name>
<affiliation wicri:level="1"><nlm:aff id="af4-etm-0-0-8207">Department of Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Department of Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022</wicri:regionArea>
<wicri:noRegion>Zhejiang 310022</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Experimental and Therapeutic Medicine</title>
<idno type="ISSN">1792-0981</idno>
<idno type="eISSN">1792-1015</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Metastasis can be a fatal step in breast cancer progression. Effective therapies are urgently required due to the limited therapeutic options clinically available. The aim of the present study was to investigate the effect of matrine (MAT), a traditional Chinese medicine, on the proliferation and migration of human breast cancer cells and its underlying mechanisms of action. The proliferation of MDA-MB-231 cells was inhibited and apoptosis was induced following treatment with MAT, as determined by MTT and Annexin-V-FITC/PI assays. Western blot analysis was used to detect the LC-3II/I levels and the results suggested that tumor autophagy is involved in the anti-tumor activity of MAT. To the best of our knowledge, this is the first study to report that MAT inhibits MDA-MB-231 and MCF-7 cell motility, potentially by targeting integrin β1 (ITGB1) and epithelial-to-mesenchymal transition (EMT), as indicated by Transwell<sup>®</sup>
and siRNA interference assays. In conclusion, ITGB1 and EMT are involved in MAT-induced breast carcinoma cell death and the inhibition of metastasis. This may lead to the development of novel compounds for the treatment of breast cancer metastasis.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Smith, Ra" uniqKey="Smith R">RA Smith</name>
</author>
<author><name sortKey="Andrews, K" uniqKey="Andrews K">K Andrews</name>
</author>
<author><name sortKey="Brooks, D" uniqKey="Brooks D">D Brooks</name>
</author>
<author><name sortKey="Desantis, Ce" uniqKey="Desantis C">CE DeSantis</name>
</author>
<author><name sortKey="Fedewa, Sa" uniqKey="Fedewa S">SA Fedewa</name>
</author>
<author><name sortKey="Lortet Tieulent, J" uniqKey="Lortet Tieulent J">J Lortet-Tieulent</name>
</author>
<author><name sortKey="Manassaram Baptiste, D" uniqKey="Manassaram Baptiste D">D Manassaram-Baptiste</name>
</author>
<author><name sortKey="Brawley, Ow" uniqKey="Brawley O">OW Brawley</name>
</author>
<author><name sortKey="Wender, Rc" uniqKey="Wender R">RC Wender</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Desantis, C" uniqKey="Desantis C">C DeSantis</name>
</author>
<author><name sortKey="Ma, J" uniqKey="Ma J">J Ma</name>
</author>
<author><name sortKey="Bryan, L" uniqKey="Bryan L">L Bryan</name>
</author>
<author><name sortKey="Jemal, A" uniqKey="Jemal A">A Jemal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Miller, Sm" uniqKey="Miller S">SM Miller</name>
</author>
<author><name sortKey="Goulet, Dr" uniqKey="Goulet D">DR Goulet</name>
</author>
<author><name sortKey="Johnson, Gl" uniqKey="Johnson G">GL Johnson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anastasiadi, Z" uniqKey="Anastasiadi Z">Z Anastasiadi</name>
</author>
<author><name sortKey="Lianos, Gd" uniqKey="Lianos G">GD Lianos</name>
</author>
<author><name sortKey="Ignatiadou, E" uniqKey="Ignatiadou E">E Ignatiadou</name>
</author>
<author><name sortKey="Harissis, Hv" uniqKey="Harissis H">HV Harissis</name>
</author>
<author><name sortKey="Mitsis, M" uniqKey="Mitsis M">M Mitsis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Simmons, A" uniqKey="Simmons A">A Simmons</name>
</author>
<author><name sortKey="Burrage, Pm" uniqKey="Burrage P">PM Burrage</name>
</author>
<author><name sortKey="Nicolau, Dv" uniqKey="Nicolau D">DV Nicolau</name>
</author>
<author><name sortKey="Lakhani, Sr" uniqKey="Lakhani S">SR Lakhani</name>
</author>
<author><name sortKey="Burrage, K" uniqKey="Burrage K">K Burrage</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhou, H" uniqKey="Zhou H">H Zhou</name>
</author>
<author><name sortKey="Xu, M" uniqKey="Xu M">M Xu</name>
</author>
<author><name sortKey="Gao, Y" uniqKey="Gao Y">Y Gao</name>
</author>
<author><name sortKey="Deng, Z" uniqKey="Deng Z">Z Deng</name>
</author>
<author><name sortKey="Cao, H" uniqKey="Cao H">H Cao</name>
</author>
<author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name>
</author>
<author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name>
</author>
<author><name sortKey="Zhang, B" uniqKey="Zhang B">B Zhang</name>
</author>
<author><name sortKey="Song, G" uniqKey="Song G">G Song</name>
</author>
<author><name sortKey="Zhan, Y" uniqKey="Zhan Y">Y Zhan</name>
</author>
<author><name sortKey="Hu, T" uniqKey="Hu T">T Hu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Zhuang, Y" uniqKey="Zhuang Y">Y Zhuang</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Ye, J" uniqKey="Ye J">J Ye</name>
</author>
<author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name>
</author>
<author><name sortKey="Wu, J" uniqKey="Wu J">J Wu</name>
</author>
<author><name sortKey="Yu, K" uniqKey="Yu K">K Yu</name>
</author>
<author><name sortKey="Han, Y" uniqKey="Han Y">Y Han</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meng, F" uniqKey="Meng F">F Meng</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Ding, F" uniqKey="Ding F">F Ding</name>
</author>
<author><name sortKey="Xie, Y" uniqKey="Xie Y">Y Xie</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Zhu, J" uniqKey="Zhu J">J Zhu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, Lp" uniqKey="Zhang L">LP Zhang</name>
</author>
<author><name sortKey="Jiang, Jk" uniqKey="Jiang J">JK Jiang</name>
</author>
<author><name sortKey="Tam, Jw" uniqKey="Tam J">JW Tam</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Liu, Xs" uniqKey="Liu X">XS Liu</name>
</author>
<author><name sortKey="Xu, Xr" uniqKey="Xu X">XR Xu</name>
</author>
<author><name sortKey="Liu, Bz" uniqKey="Liu B">BZ Liu</name>
</author>
<author><name sortKey="He, Yj" uniqKey="He Y">YJ He</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Long, Y" uniqKey="Long Y">Y Long</name>
</author>
<author><name sortKey="Lin, Xt" uniqKey="Lin X">XT Lin</name>
</author>
<author><name sortKey="Zeng, Kl" uniqKey="Zeng K">KL Zeng</name>
</author>
<author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sciacovelli, M" uniqKey="Sciacovelli M">M Sciacovelli</name>
</author>
<author><name sortKey="Frezza, C" uniqKey="Frezza C">C Frezza</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Klahan, S" uniqKey="Klahan S">S Klahan</name>
</author>
<author><name sortKey="Huang, Wc" uniqKey="Huang W">WC Huang</name>
</author>
<author><name sortKey="Chang, Cm" uniqKey="Chang C">CM Chang</name>
</author>
<author><name sortKey="Wong, Hs" uniqKey="Wong H">HS Wong</name>
</author>
<author><name sortKey="Huang, Cc" uniqKey="Huang C">CC Huang</name>
</author>
<author><name sortKey="Wu, Ms" uniqKey="Wu M">MS Wu</name>
</author>
<author><name sortKey="Lin, Yc" uniqKey="Lin Y">YC Lin</name>
</author>
<author><name sortKey="Lu, Hf" uniqKey="Lu H">HF Lu</name>
</author>
<author><name sortKey="Hou, Mf" uniqKey="Hou M">MF Hou</name>
</author>
<author><name sortKey="Chang, Wc" uniqKey="Chang W">WC Chang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zawistowski, Js" uniqKey="Zawistowski J">JS Zawistowski</name>
</author>
<author><name sortKey="Nakamura, K" uniqKey="Nakamura K">K Nakamura</name>
</author>
<author><name sortKey="Parker, Js" uniqKey="Parker J">JS Parker</name>
</author>
<author><name sortKey="Granger, Da" uniqKey="Granger D">DA Granger</name>
</author>
<author><name sortKey="Golitz, Bt" uniqKey="Golitz B">BT Golitz</name>
</author>
<author><name sortKey="Johnson, Gl" uniqKey="Johnson G">GL Johnson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Livak, Kj" uniqKey="Livak K">KJ Livak</name>
</author>
<author><name sortKey="Schmittgen, Td" uniqKey="Schmittgen T">TD Schmittgen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, J" uniqKey="Wu J">J Wu</name>
</author>
<author><name sortKey="Hu, G" uniqKey="Hu G">G Hu</name>
</author>
<author><name sortKey="Dong, Y" uniqKey="Dong Y">Y Dong</name>
</author>
<author><name sortKey="Ma, R" uniqKey="Ma R">R Ma</name>
</author>
<author><name sortKey="Yu, Z" uniqKey="Yu Z">Z Yu</name>
</author>
<author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name>
</author>
<author><name sortKey="Han, Y" uniqKey="Han Y">Y Han</name>
</author>
<author><name sortKey="Yu, K" uniqKey="Yu K">K Yu</name>
</author>
<author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ma, K" uniqKey="Ma K">K Ma</name>
</author>
<author><name sortKey="Huang, My" uniqKey="Huang M">MY Huang</name>
</author>
<author><name sortKey="Guo, Yx" uniqKey="Guo Y">YX Guo</name>
</author>
<author><name sortKey="Hu, Gq" uniqKey="Hu G">GQ Hu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Qu, X" uniqKey="Qu X">X Qu</name>
</author>
<author><name sortKey="Sheng, J" uniqKey="Sheng J">J Sheng</name>
</author>
<author><name sortKey="Shen, L" uniqKey="Shen L">L Shen</name>
</author>
<author><name sortKey="Su, J" uniqKey="Su J">J Su</name>
</author>
<author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name>
</author>
<author><name sortKey="Xie, Q" uniqKey="Xie Q">Q Xie</name>
</author>
<author><name sortKey="Wu, Y" uniqKey="Wu Y">Y Wu</name>
</author>
<author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name>
</author>
<author><name sortKey="Sun, L" uniqKey="Sun L">L Sun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kuo, S H" uniqKey="Kuo S">S-H Kuo</name>
</author>
<author><name sortKey="Tang, G" uniqKey="Tang G">G Tang</name>
</author>
<author><name sortKey="Ma, K" uniqKey="Ma K">K Ma</name>
</author>
<author><name sortKey="Babij, R" uniqKey="Babij R">R Babij</name>
</author>
<author><name sortKey="Cortes, E" uniqKey="Cortes E">E Cortes</name>
</author>
<author><name sortKey="Vonsattel, Jp" uniqKey="Vonsattel J">JP Vonsattel</name>
</author>
<author><name sortKey="Faust, Pl" uniqKey="Faust P">PL Faust</name>
</author>
<author><name sortKey="Sulzer, D" uniqKey="Sulzer D">D Sulzer</name>
</author>
<author><name sortKey="Louis, Ed" uniqKey="Louis E">ED Louis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Talmadge, Je" uniqKey="Talmadge J">JE Talmadge</name>
</author>
<author><name sortKey="Fidler, Ij" uniqKey="Fidler I">IJ Fidler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Wx" uniqKey="Li W">WX Li</name>
</author>
<author><name sortKey="Sha, Rl" uniqKey="Sha R">RL Sha</name>
</author>
<author><name sortKey="Bao, Jq" uniqKey="Bao J">JQ Bao</name>
</author>
<author><name sortKey="Luan, W" uniqKey="Luan W">W Luan</name>
</author>
<author><name sortKey="Su, Rl" uniqKey="Su R">RL Su</name>
</author>
<author><name sortKey="Sun, Sr" uniqKey="Sun S">SR Sun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xie, G" uniqKey="Xie G">G Xie</name>
</author>
<author><name sortKey="Ji, A" uniqKey="Ji A">A Ji</name>
</author>
<author><name sortKey="Yuan, Q" uniqKey="Yuan Q">Q Yuan</name>
</author>
<author><name sortKey="Jin, Z" uniqKey="Jin Z">Z Jin</name>
</author>
<author><name sortKey="Yuan, Y" uniqKey="Yuan Y">Y Yuan</name>
</author>
<author><name sortKey="Ren, C" uniqKey="Ren C">C Ren</name>
</author>
<author><name sortKey="Guo, Z" uniqKey="Guo Z">Z Guo</name>
</author>
<author><name sortKey="Yao, Q" uniqKey="Yao Q">Q Yao</name>
</author>
<author><name sortKey="Yang, K" uniqKey="Yang K">K Yang</name>
</author>
<author><name sortKey="Lin, X" uniqKey="Lin X">X Lin</name>
</author>
<author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, H" uniqKey="Li H">H Li</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
<author><name sortKey="Bai, M" uniqKey="Bai M">M Bai</name>
</author>
<author><name sortKey="Suo, Y" uniqKey="Suo Y">Y Suo</name>
</author>
<author><name sortKey="Zhang, G" uniqKey="Zhang G">G Zhang</name>
</author>
<author><name sortKey="Cao, X" uniqKey="Cao X">X Cao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, F" uniqKey="Chen F">F Chen</name>
</author>
<author><name sortKey="Huang, K" uniqKey="Huang K">K Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shao, H" uniqKey="Shao H">H Shao</name>
</author>
<author><name sortKey="Yang, B" uniqKey="Yang B">B Yang</name>
</author>
<author><name sortKey="Hu, R" uniqKey="Hu R">R Hu</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Lq" uniqKey="Li L">LQ Li</name>
</author>
<author><name sortKey="Li, Xl" uniqKey="Li X">XL Li</name>
</author>
<author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name>
</author>
<author><name sortKey="Du, Wj" uniqKey="Du W">WJ Du</name>
</author>
<author><name sortKey="Guo, R" uniqKey="Guo R">R Guo</name>
</author>
<author><name sortKey="Liang, Hh" uniqKey="Liang H">HH Liang</name>
</author>
<author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name>
</author>
<author><name sortKey="Liang, Ds" uniqKey="Liang D">DS Liang</name>
</author>
<author><name sortKey="Lu, Yj" uniqKey="Lu Y">YJ Lu</name>
</author>
<author><name sortKey="Shan, Hl" uniqKey="Shan H">HL Shan</name>
</author>
<author><name sortKey="Jiang, Hc" uniqKey="Jiang H">HC Jiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jiang, H" uniqKey="Jiang H">H Jiang</name>
</author>
<author><name sortKey="Hou, C" uniqKey="Hou C">C Hou</name>
</author>
<author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name>
</author>
<author><name sortKey="Xie, H" uniqKey="Xie H">H Xie</name>
</author>
<author><name sortKey="Zhou, W" uniqKey="Zhou W">W Zhou</name>
</author>
<author><name sortKey="Jin, Q" uniqKey="Jin Q">Q Jin</name>
</author>
<author><name sortKey="Cheng, X" uniqKey="Cheng X">X Cheng</name>
</author>
<author><name sortKey="Qian, R" uniqKey="Qian R">R Qian</name>
</author>
<author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, Ky" uniqKey="Yu K">KY Yu</name>
</author>
<author><name sortKey="Wang, Yp" uniqKey="Wang Y">YP Wang</name>
</author>
<author><name sortKey="Wang, Lh" uniqKey="Wang L">LH Wang</name>
</author>
<author><name sortKey="Jian, Y" uniqKey="Jian Y">Y Jian</name>
</author>
<author><name sortKey="Zhao, Xd" uniqKey="Zhao X">XD Zhao</name>
</author>
<author><name sortKey="Chen, Jw" uniqKey="Chen J">JW Chen</name>
</author>
<author><name sortKey="Murao, K" uniqKey="Murao K">K Murao</name>
</author>
<author><name sortKey="Zhu, W" uniqKey="Zhu W">W Zhu</name>
</author>
<author><name sortKey="Dong, L" uniqKey="Dong L">L Dong</name>
</author>
<author><name sortKey="Wang, Gq" uniqKey="Wang G">GQ Wang</name>
</author>
<author><name sortKey="Zhang, Gx" uniqKey="Zhang G">GX Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, X" uniqKey="Wu X">X Wu</name>
</author>
<author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name>
</author>
<author><name sortKey="Cai, D" uniqKey="Cai D">D Cai</name>
</author>
<author><name sortKey="Li, M" uniqKey="Li M">M Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name>
</author>
<author><name sortKey="Yu, P" uniqKey="Yu P">P Yu</name>
</author>
<author><name sortKey="Liu, Q" uniqKey="Liu Q">Q Liu</name>
</author>
<author><name sortKey="Liu, K" uniqKey="Liu K">K Liu</name>
</author>
<author><name sortKey="Duan, H" uniqKey="Duan H">H Duan</name>
</author>
<author><name sortKey="Luan, G" uniqKey="Luan G">G Luan</name>
</author>
<author><name sortKey="Yagasaki, K" uniqKey="Yagasaki K">K Yagasaki</name>
</author>
<author><name sortKey="Zhang, G" uniqKey="Zhang G">G Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name>
</author>
<author><name sortKey="Wang, T" uniqKey="Wang T">T Wang</name>
</author>
<author><name sortKey="Wen, X" uniqKey="Wen X">X Wen</name>
</author>
<author><name sortKey="Wei, Y" uniqKey="Wei Y">Y Wei</name>
</author>
<author><name sortKey="Peng, X" uniqKey="Peng X">X Peng</name>
</author>
<author><name sortKey="Li, H" uniqKey="Li H">H Li</name>
</author>
<author><name sortKey="Wei, L" uniqKey="Wei L">L Wei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hynes, Ro" uniqKey="Hynes R">RO Hynes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, Z" uniqKey="Xu Z">Z Xu</name>
</author>
<author><name sortKey="Zou, L" uniqKey="Zou L">L Zou</name>
</author>
<author><name sortKey="Ma, G" uniqKey="Ma G">G Ma</name>
</author>
<author><name sortKey="Wu, X" uniqKey="Wu X">X Wu</name>
</author>
<author><name sortKey="Huang, F" uniqKey="Huang F">F Huang</name>
</author>
<author><name sortKey="Feng, T" uniqKey="Feng T">T Feng</name>
</author>
<author><name sortKey="Li, S" uniqKey="Li S">S Li</name>
</author>
<author><name sortKey="Lin, Q" uniqKey="Lin Q">Q Lin</name>
</author>
<author><name sortKey="He, X" uniqKey="He X">X He</name>
</author>
<author><name sortKey="Liu, Z" uniqKey="Liu Z">Z Liu</name>
</author>
<author><name sortKey="Cao, X" uniqKey="Cao X">X Cao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jahangiri, A" uniqKey="Jahangiri A">A Jahangiri</name>
</author>
<author><name sortKey="Nguyen, A" uniqKey="Nguyen A">A Nguyen</name>
</author>
<author><name sortKey="Chandra, A" uniqKey="Chandra A">A Chandra</name>
</author>
<author><name sortKey="Sidorov, Mk" uniqKey="Sidorov M">MK Sidorov</name>
</author>
<author><name sortKey="Yagnik, G" uniqKey="Yagnik G">G Yagnik</name>
</author>
<author><name sortKey="Rick, J" uniqKey="Rick J">J Rick</name>
</author>
<author><name sortKey="Han, Sw" uniqKey="Han S">SW Han</name>
</author>
<author><name sortKey="Chen, W" uniqKey="Chen W">W Chen</name>
</author>
<author><name sortKey="Flanigan, Pm" uniqKey="Flanigan P">PM Flanigan</name>
</author>
<author><name sortKey="Schneidman Duhovny, D" uniqKey="Schneidman Duhovny D">D Schneidman-Duhovny</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jiang, R" uniqKey="Jiang R">R Jiang</name>
</author>
<author><name sortKey="Zhang, C" uniqKey="Zhang C">C Zhang</name>
</author>
<author><name sortKey="Liu, G" uniqKey="Liu G">G Liu</name>
</author>
<author><name sortKey="Gu, R" uniqKey="Gu R">R Gu</name>
</author>
<author><name sortKey="Wu, H" uniqKey="Wu H">H Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Araki, K" uniqKey="Araki K">K Araki</name>
</author>
<author><name sortKey="Shimura, T" uniqKey="Shimura T">T Shimura</name>
</author>
<author><name sortKey="Suzuki, H" uniqKey="Suzuki H">H Suzuki</name>
</author>
<author><name sortKey="Tsutsumi, S" uniqKey="Tsutsumi S">S Tsutsumi</name>
</author>
<author><name sortKey="Wada, W" uniqKey="Wada W">W Wada</name>
</author>
<author><name sortKey="Yajima, T" uniqKey="Yajima T">T Yajima</name>
</author>
<author><name sortKey="Kobayahi, T" uniqKey="Kobayahi T">T Kobayahi</name>
</author>
<author><name sortKey="Kubo, N" uniqKey="Kubo N">N Kubo</name>
</author>
<author><name sortKey="Kuwano, H" uniqKey="Kuwano H">H Kuwano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Hao, Y" uniqKey="Hao Y">Y Hao</name>
</author>
<author><name sortKey="Mao, W" uniqKey="Mao W">W Mao</name>
</author>
<author><name sortKey="Xue, X" uniqKey="Xue X">X Xue</name>
</author>
<author><name sortKey="Xu, P" uniqKey="Xu P">P Xu</name>
</author>
<author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name>
</author>
<author><name sortKey="Yuan, J" uniqKey="Yuan J">J Yuan</name>
</author>
<author><name sortKey="Zhang, D" uniqKey="Zhang D">D Zhang</name>
</author>
<author><name sortKey="Li, N" uniqKey="Li N">N Li</name>
</author>
<author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name>
</author>
<author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name>
</author>
<author><name sortKey="Zhang, Py" uniqKey="Zhang P">PY Zhang</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Sun, Sy" uniqKey="Sun S">SY Sun</name>
</author>
<author><name sortKey="Yu, Sy" uniqKey="Yu S">SY Yu</name>
</author>
<author><name sortKey="Xi, Qs" uniqKey="Xi Q">QS Xi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ding, Y" uniqKey="Ding Y">Y Ding</name>
</author>
<author><name sortKey="Pan, Y" uniqKey="Pan Y">Y Pan</name>
</author>
<author><name sortKey="Liu, S" uniqKey="Liu S">S Liu</name>
</author>
<author><name sortKey="Jiang, F" uniqKey="Jiang F">F Jiang</name>
</author>
<author><name sortKey="Jiao, J" uniqKey="Jiao J">J Jiao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, Yy" uniqKey="Zhang Y">YY Zhang</name>
</author>
<author><name sortKey="Kong, Lq" uniqKey="Kong L">LQ Kong</name>
</author>
<author><name sortKey="Zhu, Xd" uniqKey="Zhu X">XD Zhu</name>
</author>
<author><name sortKey="Cai, H" uniqKey="Cai H">H Cai</name>
</author>
<author><name sortKey="Wang, Ch" uniqKey="Wang C">CH Wang</name>
</author>
<author><name sortKey="Shi, Wk" uniqKey="Shi W">WK Shi</name>
</author>
<author><name sortKey="Cao, Mq" uniqKey="Cao M">MQ Cao</name>
</author>
<author><name sortKey="Li, Xl" uniqKey="Li X">XL Li</name>
</author>
<author><name sortKey="Li, Ks" uniqKey="Li K">KS Li</name>
</author>
<author><name sortKey="Zhang, Sz" uniqKey="Zhang S">SZ Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name>
</author>
<author><name sortKey="Hou, Y" uniqKey="Hou Y">Y Hou</name>
</author>
<author><name sortKey="Zhou, M" uniqKey="Zhou M">M Zhou</name>
</author>
<author><name sortKey="Wen, S" uniqKey="Wen S">S Wen</name>
</author>
<author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name>
</author>
<author><name sortKey="Xu, L" uniqKey="Xu L">L Xu</name>
</author>
<author><name sortKey="Tang, X" uniqKey="Tang X">X Tang</name>
</author>
<author><name sortKey="Du, Ye" uniqKey="Du Y">YE Du</name>
</author>
<author><name sortKey="Hu, P" uniqKey="Hu P">P Hu</name>
</author>
<author><name sortKey="Liu, M" uniqKey="Liu M">M Liu</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Ren, Lili" sort="Ren, Lili" uniqKey="Ren L" first="Lili" last="Ren">Lili Ren</name>
</noRegion>
<name sortKey="Mo, Wenju" sort="Mo, Wenju" uniqKey="Mo W" first="Wenju" last="Mo">Wenju Mo</name>
<name sortKey="Wang, Linling" sort="Wang, Linling" uniqKey="Wang L" first="Linling" last="Wang">Linling Wang</name>
<name sortKey="Wang, Xiaojia" sort="Wang, Xiaojia" uniqKey="Wang X" first="Xiaojia" last="Wang">Xiaojia Wang</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000650 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000650 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:6909565 |texte= Matrine suppresses breast cancer metastasis by targeting ITGB1 and inhibiting epithelial-to-mesenchymal transition }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31853313" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
This area was generated with Dilib version V0.6.33. |